Uncharted 4 sai omale uue Survival mängumoodi. Survival on uus co-op mood kus sina ja kaks sinu sõpra saavad madistada vaenlaste vastu kuni 50 rünnakulainet. Soovi korral võid seda muidugi ka üksi proovida.
Lisaks uule progresseeruvale süsteemile, erinevalete tasemetele, lahti lukustavatele tasudele, tuleb uue mängumoodiga kaasa ka uued Trofeed.
Koos uue Survival mängumoodiga lisati uuendusega juurde ka palju muud, seal hulgas kaks uut kaarti, klassikalised relvad, uus mängumood King of the Hill ja palju muud.
New maps: Train Wreck (from Uncharted 2) and Prison
New beta test Playlist Mode: King of the Hill – teams to compete to retain control of a single Hill and earn Victory Points. Respawning restricted when your team controls the Hill
New character skins: 48 new character skins, including new Biker-themed skins
New colour customisation: Customise any character skin with 25 unique color variants
New multiplayer levels and rewards: Max rank increased to Level 90 with two new vanity unlocks
New Challenges: Earn Relics with new Challenges for multiplayer and Survival
